​We have a Sunday night clash between the ACC and SEC when Louisville and Ole Miss meet in the Music City. At Nissan Stadium in Nashville, TN, the Cardinals and Rebels attempt to each start the season with a resume building win.Louisville played and beat Eastern Kentucky, James Madison, Bowling Green, and Kentucky in non-conference play last year. The Cardinals started the season 7-1 (4-1) before losing three straight to push them out of the ACC Conference Championship chase. Louisville ended the season with a win over Kentucky, then a 27-22 win the Boca Raton Bowl. Louisville was picked third in the ACC Preseason Poll entering this season and has a strong offensive line put together via the portal with 142 career starts.Ole Miss was arguably the most exciting team in the college football playoff last season and had to do it without their head coach. Pete Golding takes over at the helm and he will have it easy thanks to Trinidad Chambliss (3,937 passing yards, 22 TDs, 3 INT) and Kewan Lacy (1,567 rushing yards, 24 TDs) returning to the Rebels. Ole Miss ended up having three ranked opponents on the schedule last season, but this year they have a whopping six! — at least for now.Let’s dive into the schools on both sides of the ball, look at a few key players, and see where the numbers take us.Game Details and How to Watch Louisville vs Ole MissDate: Sunday, September 6, 2026Time: 7:30PM EasternSite: Nissan StadiumCity: Nashville, TNTV/Streaming: ABC / ESPNGame Odds for Louisville vs Ole MissThe latest odds as of Monday courtesy of DraftKings:Moneyline: Ole Miss Rebels (-258), Louisville Cardinals (+210)Spread: Ole Miss -6.5 (-115)Total: 55.5 pointsBe sure to check out DraftKings for all the latest game odds & player props for every matchup this week on the college football schedule!Louisville CardinalsHead Coach: Jeff Brohm2025 Record: 9-4 (4-4)Offensive Points Per Game: 29.9 (49th)Defensive Points Per Game: 21.1 (38th)2025 Strength of Schedule: 53rd2026 Strength of Schedule: 58thThe Louisville Cardinals Offense:In 2025, Louisville scored 30 or more points in five of 13 games. However, they slipped down the stretch with 26 (OT), 19, and 6 points in three losses that spanned over the final four regular season games. The Cardinals move on from Miller Moss to Lincoln Kienholz, the former Ohio State Buckeye. Kienholz has been a backup for Ohio State and only attempted 36 passes in his three-year career (3 total TDs, 318 yards). The Cardinals finished 75th in passing yards per game (220.6) last year and 72nd in passing efficiency (131.65).Louisville Player to Watch on Offense: RB Issac BrownIn 2024, Isaac Brown became the first-ever freshman to run for 1,000 yards at Louisville! Brown recorded 1,173 yards and 13 touchdowns on the ground and would have topped those numbers in 2025 if it wasn’t for an injury. Brown missed four games and finished the season with 884 rushing yards and seven touchdowns on 101 carries — 64 less attempts than the year