​The Tennessee Titans have little room for error heading into their Week 2 matchup against the Philadelphia Eagles at home.Tennessee opened the 2026 season with a 23-10 home loss to the New York Jets, while giving up 367 to 195 in total yards. Philadelphia, meanwhile, survived the Washington Commanders 24-22 behind three touchdown passes from Jalen Hurts.The Titans remain home for what is expected to be a tougher test. Here are three key matchups that could have a major impact on how Sunday’s game unfolds.Jeffery Simmons vs. Eagles interior offensive lineIf the Titans are going to slow down Philadelphia’s offense, Jeffery Simmons will need to be a major factor. Simmons is coming off a very quiet Week 1, in which he didn’t garner a QB Hit or sack.He is Tennessee’s most important defensive player, and this matchup could become especially important on passing downs. If Simmons can rebound from a subpar Week 1 and generate interior pressure without requiring extra blitzers, the Titans can pull off the upset.Cam Ward vs. the Eagles pass rushA lot has been made of Cam Ward and the offense’s slow start to the season. Ward, in particular, completed 19 of 32 passes for only 140 yards and a touchdown against the Jets, while the Titans offensive line struggled to protect him consistently.The challenge gets even tougher against Philadelphia, which is known to present a strong defensive front. Ward will need to make quicker decisions and find ways to use the Eagles’ aggression against it. If Ward gets time, Tennessee should have enough receiving talent to make Philadelphia defend the entire field.Titans run defense vs. Jalen Hurts and Saquon BarkleyEagles QB Jalen Hurts brings an additional rushing threat to the Eagles’ offense, while RB Saquon Barkley gives them a proven home-run threat in the backfield. Tennessee’s run defense allowed Jets’ RB Breece Hall to control their Week 1 matchup with over 100 yards rushing.That creates a tough assignment for Tennessee’s front seven, as they need to limit Barkley’s explosive runs while staying disciplined against Hurts when he leaves the pocket. If Tennessee can force Philadelphia into obvious passing situations, Simmons and the rest of the pass rush can become more impactful.This article originally appeared on Titans Wire: Tennessee Titans vs. Philadelphia Eagles: 3 key matchups for Week 2