​SANTA CLARA, CALIFORNIA – OCTOBER 04: Bo Nix #10 of the Denver Broncos looks on while warming up prior to the start of the game against the San Francisco 49ers at Levi’s Stadium on October 04, 2026 in Santa Clara, California. (Photo by Thearon W. Henderson/Getty Images) | Getty Images The Denver Broncos will be on the road in Week 4 to take on the undefeated San Francisco 49ers. Denver is fresh off back-to-back comeback wins to overcome double-digit deficits in each. They’ll need to play a much cleaner game this week and discover how to perform well in the first half for a change. Kickoff is set for 2:25 p.m. Mile High time on Sunday, October 4, 2026 at Levi’s Stadium in Santa Clara, California. You can watch the live stream of the game through FuboTV or on CBS. The game will be called by Kevin Harlan (play-by-play), Trent Green (analyst), and Melanie Collins (sideline). You can also check local Broncos radio network affiliate stations. Join the conversation!Sign up for a user account and get:Fewer adsCreate community postsComment on articles, community postsRec comments, community postsNew, improved notifications system!Download the SB Nation app on iOS or Android.Broncos vs. 49ers score predictionsThis is one of those games where I think the Broncos won’t be able to catch fire late. A combination of the heat, poor starts, and inability to sustain drives will catch Denver sleeping. They will mount a late drive, but the defense is too tired to rally. It’s okay, though. Losing on the road to an NFC team is the “best” kind of loss and the Broncos will bounce-back to win the next two games anyway. 4-2 through the first six games was always my target.49ers 27, Broncos 16.Join the discussion in the comments section below.Broncos vs. 49ers live updates🔙 in Summit White for #DENvsSF 🥶 pic.twitter.com/ql73evKpD5— Denver Broncos (@Broncos) October 4, 2026Bring ‘em out 🗣️📺: @CBSSports / @paramountpluspic.twitter.com/JpzwZvTsX8— Denver Broncos (@Broncos) October 4, 2026Bo Nix, Talanoa Hufanga, Alex Singleton, Quinn Meinerz and Devon Key are the Broncos’ game-day captains.San Francisco wins the toss and defers. Denver’s offense is up first.— Aric DiLalla (@AricDiLalla) October 4, 20263rd and 8..Sutton falls down and the Broncos go 3 and out.— MileHighReport (@MileHighReport) October 4, 2026#Broncos defense gets off the field. Dime rep on third-and-7 featured just a three-man rush and Bonitto bailing out into coverage.— Parker Gabriel (@ParkerJGabriel) October 4, 2026Tyler Badie and the Broncos needed 3 yards and they got 25 😤DENvsSF on CBS/Paramount+Stream on @NFLPluspic.twitter.com/QdbJCTwtbJ— NFL (@NFL) October 4, 2026Wil Lutz is GOOD from 52 yardsBroncos: 349ers: 0— MileHighReport (@MileHighReport) October 4, 2026BRONCOS BALLTURNOVER ON DOWNQB Sneak is STUFFED by the Broncos.— Zac Stevens (@ZacStevens) October 4, 2026Big stop 😤📺: @CBSSports / @paramountpluspic.twitter.com/4kdC8cZm1P— Denver Broncos