​Oct 4, 2025; East Hartford, Connecticut, USA; FIU Panthers head coach Willie Simmons watches from the sideline as they take on the UConn Huskies at Pratt & Whitney Stadium at Rentschler Field. Mandatory Credit: David Butler II-Imagn Images
The Buffalo Bulls take on the Florida International Panthers in Miami, Fla. Kickoff is set for 6:00 p.m. EDT on ESPN+.FIU is favored by 9.5 points on the spread with a moneyline of -410. The total is set at 47.5 points.Here’s my Buffalo vs. FIU prediction and college football pick for Saturday, September 12, 2026.Buffalo vs. FIU Pick: FIU -10 or BetterMy FIU vs. Buffalo best bet is on the Panthers. Find the best line available on our live NCAAF odds page.Buffalo vs FIU OddsBuffalo vs FIU point spread: FIU -9.5 (-120), Buffalo +9.5 (-102)Buffalo vs FIU over/under: 47.5 (-110o / -110u)Buffalo vs FIU moneyline: Buffalo +315, FIU -410Two teams with opposite Week 1 box scores 1 are set to collide in Week 2.Starting in the MAC, Buffalo survived Albany’s onslaught and escaped with a 21-17 victory. The Bulls held the narrow edge in yards per play on the Great Danes but committed 10 penalties for 119 yards.Quarterback Elijah Holmes did have a fantastic game, though, with three touchdowns. However, Buffalo pass-catchers combined for a total of five drops.One box score fraud from Week 1 came in Florida International’s loss to South Florida.The Panthers traveled north to Tampa and nearly doubled the Bulls in total yards. USF checked in at 3.7 overall yards per play, well short of FIU at 5.1.The downfall came in the turnover department, as the Panthers went 3-for-7 on fourth-down attempts. Three of their final four possessions also ended with an interception or fumble.The updated Action Network Betting Power Ratings project FIU as a favorite by more than two touchdowns over Buffalo in Week 2.The Panthers are sure to fix their offensive turnovers, while the Bulls must execute better after drawing double-digit penalties in their narrow escape against an FCS foe.Pick: FIU -10 or Better