​The Los Angeles Chargers are missing three key players for their marquee game against the Denver Broncos, making a must-win contest even tougher. The Chargers have lost all four games so far this season, and with the team playing a bad brand of football and taking a notable step back, they face ample pressure to start performing.Now, things get even harder at home, with a hostile traveling crowd and a Broncos team looking to get back on track. Oct 4, 2026; Seattle, Washington, USA; Los Angeles Chargers head coach Jim Harbaugh is seen against the Seattle Seahawks during the first half at Lumen Field. Mandatory Credit: Joe Nicholson-Imagn ImagesWho is injured for the ChargersThe Chargers are missing safety Derwin James, left tackle Joe Alt, and receiver Quentin Johnston for Week 5. James is the defensive leader and the unit’s best player, able to make plays and operate quietly, taking away opposing players.However, he is out with a hamstring injury. Alt is missing this upcoming week with a neck injury, and Johnston is out with a chest issue. Additionally, Rashawn Slater is going to the injured reserve with an ankle injury, making Alt’s absence even more felt with both bookend tackles gone from the rotation. Johnston hasn’t been great this year, but he is a veteran receiver for Herbert to lean on. However, with him out and Ladd McConkey questionable with a foot injury, continuing a concerning injury trend, Herbert will lose his top option and lean even more on second-year player Tre Harris.Oct 4, 2026; Seattle, Washington, USA; Los Angeles Chargers quarterback Justin Herbert (10) throws a pass against the Seattle Seahawks during the second half at Lumen Field. Mandatory Credit: Steven Bisig-Imagn ImagesHow can the Chargers replace themAs mentioned, Harris will be a key receiver, regardless of McConkey’s status, while Marquez Valdes-Scantling will take on a bigger role. Defensively, the Chargers have been much better than offensively, leaving offensive coordinator Mike McDaniel with real work to do in the scheme, with receivers open and less burden on the offense. A quick passing game and some inside running can help offset the lack of receivers and starting offensive tackles. The post Chargers’ Nightmare Start Gets Worse With 3 Key Players Ruled Out appeared first on LA Sports Report.