​Fantasy Football Start ‘Em, Sit ‘Em: Week 4 lineup advice, best matchups, DFS picks originally appeared on The Sporting News.
Add The Sporting News as a Preferred Source by clicking here.Welcome to Week 4 in another NFL season of fantasy football start and sit lineup advice from The Sporting News.Vinnie Iyer’s analysis, aka “The Decider,” remains your one-stop shop for fantasy start ’em/sit ’em in 2026 — a unique mashup of rankings and matchup breakdowns to help you make those tough decisions on whom to play and not to play:Several high-drafted fantasy players who should be in lineups most weeks when healthy and active are the “must starts.”Borderline options with favorable matchups are “stronger starts,” while the recommended plays to avoid are “weaker starts.”The advice is based on 12-team, half-point PPR to split the difference between shallow and deep leagues and full-PPR and standard formats.Going beyond redraft league starts and sits, “The Decider” also includes some DFS picks for different styles of games on DraftKings and FanDuel. Keep scrolling for tips on how to deploy the best fantasy football lineup for your league opener.FANTASY FOOTBALL TOOLS: News | Stats | Transactions | Depth Charts | InjuriesFantasy Football Week 4 Start ‘Em: QuarterbacksMust-start Week 4 QBsJosh Allen, Bills (vs. NE)Lamar Jackson, Ravens (vs. TEN)Patrick Mahomes, Chiefs (at LV)Jalen Hurts, Eagles (vs. LAR)Brock Purdy, 49ers (vs. DEN)Strong Week 4 QB starts6. Trevor Lawrence, Jaguars (at CIN): T-Law, even with that savvy fantasy-unfriendly kneel against the Patriots, is balling and he should light it up opposite … 7. Joe Burrow, Bengals (vs. JAX): … Burrow, who is getting plenty of help from his elite two wide receivers and then some all over the field.8. Jared Goff, Lions (at CAR): Goff has been less volatile on the road and the Panthers’ defense is weakened on the back end.9. Tyler Shough, Saints (vs. ATL): Shough keeps on chucking and that won’t stop in an emotional night at home against a beatable defense that won’t pressure him much.10. Matthew Stafford, Rams (at PHI): Stafford will need to keep on passing here with the Rams having some major defensive breakdowns.11. Dak Prescott, Cowboys (at HOU): The Texans’ defense isn’t so intimidating and his receivers can still get the best of their whiffing secondary.12. Kyler Murray, Vikings (vs. MIA): Kyler the creator will find a way to get it done with arms and legs against a Dolphins D with little resistance.13. Jordan Love, Packers (vs. TB): He’s feeling it in a one-dimensional offense with a clear dynamite trio of targets.14. Bryce Young, Panthers (vs. DET): Let’s give him a good chance to rebound at home against the Lions, who can’t stop the pass at all.MORE:Trevor Lawrence gives hilarious reason for kneeling at the 1-yard lineDFS QB Week 4 pickTrevor Lawrence, Jaguars (at CIN, $5,900 on DraftKings, $7,900 on FanDuel): Lawrence can explode in this game with high volume and the