​The 2026 regular season has arrived and we’ve got a healthy dose of NFL Week 1 picks in store. Wednesday’s season-opener and Super Bowl 60 rematch got things started with the Seattle Seahawks beating the New England Patriots, again.However, NFL fans still have three more days to enjoy Week 1 games with an expanded football calendar. Roger Goodell and the league have put out some excellent matchups, including the first-ever Australia game on Thursday.Meanwhile, other playoff teams from a season ago will be in high demand this weekend. The Buffalo Bills, Chicago Bears and Jacksonville Jaguars are all explosive offensives that fans are hyped to watch.Without further ado, let’s jump into our picks and predictions for the NFL games remaining on the Week 1 slate.MORE: NFL announcer schedule & pairings for Week 1 of 2026 seasonNFL Week 1 picks & predictionsSan Francisco 49ers running back Christian McCaffrey during training camp at SAP Performance Facility. Mandatory Credit: Sergio Estrada-Imagn Images Credit: IMAGN IMAGES via Reuters Connect (Reuters)Thursday, September 10San Francisco 49ers vs. Los Angeles Rams in Melbourne, Australia (8:35 p.m., Netflix)These two NFC West teams are being closely watched after traveling across the world. The Rams only arrived 24 hours before kickoff, while the 49ers have been in Australia for nearly a week.Both teams have deep playoff aspirations again, but it’s easier to trust Matthew Stafford and Co. after a tumultuous offseason for San Francisco.Rams 27, 49ers 20Sunday, September 13Baltimore Ravens at Indianapolis Colts (1 p.m., CBS)Lamar Jackson and Baltimore had a quiet offseason, but that’s not a bad thing for a team with a new head coach. The Ravens are always dangerous with their rushing attack, and Indy simply looks like they’ll struggle to contain Jackson and Co.Meanwhile, the Colts are hopeful that Daniel Jones can return to form in 2026 after a devastating injury derailed Indianapolis’ campaign a season ago.Ravens 30, Colts 21Buffalo Bills at Houston Texans (1 p.m., CBS)The Bills are entering their first season with Joe Brady leading the way as head coach. Buffalo’s offense might get even more exciting with Josh Allen, DJ Moore and James Cook guiding the way.However, NFL fans will learn a lot right away about Buffalo’s Super Bowl chances against a dominant Houston defense.Bills 24, Texans 14Jacksonville Jaguars quarterback Trevor Lawrence throws the ball during the second quarter of an NFL football AFC Wild Card playoff matchup. [Corey Perrine/Florida Times-Union] Credit: USA TODAY Network via Reuters Connect (Reuters)Cleveland Browns at Jacksonville Jaguars (1 p.m., CBS)The Jaguars are expected to be even better in Year 2 under Liam Coen. Trevor Lawrence looks fully in command of Jacksonville’s playbook and his WR options are aplenty.It’s also hard to see a world where Cleveland magically overcomes DeShaun Watson’s brutal offseason. The Browns have weapons on offense, but W