​The San Francisco 49ers have the chance to establish full control of the NFC West. The NFL slate doesn’t have a lot of games to be excited about, but the 49ers taking on the Seattle Seahawks gives us excitement for our NFL Week 5 picks and predictions.Last week, we bounced back with a strong 10-6 showing. That brings TBL’s season-long picks record to 36-27 with another 16-game picks preview upcoming.The NFL heads abroad to London for the second straight weekend as the Philadelphia Eagles and Jacksonville Jaguars meet. Meanwhile, Monday Night Football features an epic quarterback matchup with Josh Allen and the Buffalo Bills facing off against Matthew Stafford and the Los Angeles Rams.Which Week 5 games are you going to be focused on? Will there be any significant upsets around the NFL this weekend?MORE: Which NFL game should be nationally televised in Week 5?NFL Week 5 picks & predictionsDallas Cowboys quarterback Dak Prescott (4) talks with referee Brad Allen (122) during the first half against the Houston Texans at Reliant Stadium. Mandatory Credit: Thomas Shea-Imagn Images Credit: IMAGN IMAGES via Reuters Connect (Reuters)Thursday, October 8Tampa Bay Buccaneers at Dallas Cowboys (8:15 p.m., Prime Video)This one is pretty simple. Dallas has an elite offense and just got one of its top offensive lineman back from IR. Meanwhile, the Bucs are 0-4 and Baker Mayfield remains on the sidelines. Pick: Cowboys 37, Buccaneers 16Sunday, October 11Philadelphia Eagles vs. Jacksonville Jaguars in London (9:30 a.m., NFL Network)This game could very well be the final nail in the Eagles’ season after their recent struggles. Jacksonville essentially plays a home game in front of its annual London crowd and the Jaguars are among the NFL’s best teams. Pick: Jaguars 28, Eagles 14Cleveland Browns at New York Jets (1 p.m., CBS)Deshaun Watson is actually playing good football and the Browns are 3-1 because of that fact. The Jets are still battling some injuries, including Breece Hall’s absence. Cleveland continues its shocking start to the season. Pick: Browns 24, Jets 17Houston Texans at Tennessee Titans (1 p.m., CBS)Houston’s season is almost off the rails after four games, but they have the perfect matchup to secure their first win. The Titans look discombobulated on offense and Cam Ward’s time as the starter could already be running out. Pick: Texans 31, Titans 14Indianapolis Colts at Pittsburgh Steelers (1 p.m., CBS)This is one of the most underrated games on the Week 5 schedule. Both teams have had their ups and downs in 2026, but the offenses can score points. This matchup comes down to Pittsburgh’s defense getting key pressure on Daniel Jones in crunch time. Pick: Steelers 28, Colts 27MORE: NFL announcer schedule & pairings for Week 5 of 2026 seasonNew England Patriots quarterback Drake Maye (10) throws a pass during the third quarter against the Buffalo Bills at New Highmark Stadium. Mandatory Credit: Gregory Fisher-Imagn Images Cred