​The Los Angeles Chargers have plenty of talent in their running back room, but their second preseason game raised a legitimate question. What happens if Omarion Hampton goes down with an injury and has to miss an extended period of time?The Bolts were blown out 41-17 by the San Francisco 49ers on Thursday night, and their rushing attack struggled to generate much of anything outside of one explosive run. The production was concerning because several players competing for roster spots failed to make their presence felt.Greg Desrosiers Jr. led the group with 21 yards on four carries, while Jaret Patterson finished with seven yards on three attempts. Kimani Vidal had six yards on four carries, and Keaton Mitchell managed just negative-one yard on three attempts. Amar Johnson, the standout of the preseason opener, had negative-one yard on two carries, while Hampton himself had negatice-one yard on one carries.Backup quarterback Trey Lance actually produced the game’s most explosive run for the Chargers, breaking off a 37-yard gain while finishing with 42-yards on two attempts.The Bolts entered the preseason with an intriguing running back room. Hampton is expected to be the lead back, while Mitchell and Vidal are pretty much locks behind him. However, Patterson and the undrafted Desrosiers and Johnson are competing for opportunities behind him.There is reason to believe the group can be better than it looked against San Francisco. Mitchell brings legitimate explosiveness and speed when healthy, while Vidal has already shown flashes in his young career. Desrosiers, meanwhile, has been one of the more interesting undrafted players in the competition and previously showed promise during the preseason opener.But if Hampton were to miss significant time, the Bolts would likely need several of those players to step up rather than expecting one immediate replacement to replicate what Hampton brings.While the performance on Thursday was concerning, one preseason game shouldn’t dictate how the Chargers evaluate their depth.San Francisco’s defense is talented, and preseason rotations can make offensive production difficult to judge. The Chargers also weren’t necessarily giving their backup backs ideal circumstances to succeed.So, is it concerning? A little, but not worthy any panic.The bigger issue isn’t that the backups struggled in one game. It’s whether the Chargers can identify two or three backs capable of consistently producing before the regular season begins. If Hampton stays healthy, this may ultimately be nothing more than an ugly preseason box score. If he doesn’t, however, the Chargers need someone behind him to prove this game was the exception rather than the warning sign.